Karen Friedman Agnifilo, defense attorney, Luigi Mangione case
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Defense Attorney

Karen Friedman Agnifilo

Defense attorney for Luigi Mangione. Formerly Chief Assistant District Attorney, Manhattan.
1 case·37 media appearances

Profile

RoleDefense Attorney
Legal statusDefense attorney for Luigi Mangione. Formerly Chief Assistant District Attorney, Manhattan.
WikipediaRead article →

About

Lead defense attorney for Luigi Mangione in the UnitedHealthcare CEO murder case. Former Chief Assistant District Attorney under Manhattan DA Cyrus Vance Jr., she transitioned to criminal defense and is a partner at Agnifilo Intrater LLP. Her high-profile representation of Mangione drew significant media attention.

Sources: Wikipedia: Karen Friedman Agnifilo

Career

2021 – present

Partner

Agnifilo Intrater

2014 – 2021

Chief Assistant District Attorney

Manhattan District Attorney Office

2010 – 2014

Executive ADA / Chief of the Trial Division

Manhattan District Attorney Office

2006 – 2010

General Counsel

NYC Mayor Office of Criminal Justice

1992 – 2006

Assistant District Attorney / Deputy Chief, Sex Crimes Unit

Manhattan District Attorney Office

Connected case

Charges FiledDefense Attorney

UnitedHealthcare CEO Shooting

Brian Thompson, the CEO of the American health insurance company UnitedHealthcare, was shot and killed in Midtown Manhattan, New York City, on December 4, 2024. The shooting occurred early in the morning outside an entrance to the New York Hilton Midtown. The suspect, initially described as a white man wearing a mask, fled the scene. The words "delay", "deny", and "depose" were inscribed on the cartridge cases used during the shooting. Thompson had previously faced criticism for the company's rejection of insurance claims, and his family reported that he had received death threats.

Related people

Media appearances

Luigi Mangione Gets Spared; Death Penalty Taken off the Table as he faces charges for Murder of CEO

Luigi Mangione: STS Files · Feb 3, 2026 · 22m

In-app player

BARD - Don Lemon, Luigi Mangione, and the Limits of Federal Power

Reasonable Doubt · Feb 1, 2026 · 20m

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Reacting To This ABSURD Story Regarding Luigi Mangione

The Valenti Show · Jan 29, 2026 · 7m

In-app player

Luigi Mangione - Part Two: On Pain of Death | #432

RedHanded · Jan 15, 2026 · 1h 9m

In-app player

Does Luigi Mangione have a ‘real shot?’; rumors in Tepe's murders | Banfield Full Episode 1/9

Banfield · Jan 11, 2026 · 41m

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Luigi Mangione - Part One: “Deny, Defend, Depose” | #431

RedHanded · Jan 8, 2026 · 56m

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Luigi Mangione's Defense Argue Arrest Details & Body Cam Video Concerns May Jeopardize a Fair Trial

Luigi Mangione: STS Files · Dec 24, 2025 · 19m

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Back In Court on Anniversary of CEO Killing: Will Key Evidence Be Thrown Out In Luigi Mangione Trial

Luigi Mangione: STS Files · Dec 24, 2025 · 22m

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What Really Happened in That McDonald’s: Mangione’s Breakdown Exposed-WEEK IN REVIEW

United Healthcare Murder: The Luigi Mangione Story · Dec 14, 2025 · 41m

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The Case Against Luigi Mangione | Vinnie Politan Investigates Podcast

Court TV Podcast · Dec 13, 2025

Listen

Ret FBI Coffindaffer Breaks Down Two Murderous Narcissists: Luigi Mangione & Brian Walshe

United Healthcare Murder: The Luigi Mangione Story · Dec 10, 2025 · 51m

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What Luigi Mangione Carried, What Brian Walshe Hid, and What Happened to Pregnant Mother Rebecca Park

True Crime Tonight · Dec 9, 2025 · 1h 34m

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BOMBSHELL: Here's Why Luigi Mangione Will Get Off! w/ Nick Cruse

The Jimmy Dore Show · Dec 5, 2025 · 1h 1m

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Was Key Luigi Mangione Evidence Illegal? Inside His Courtroom War

United Healthcare Murder: The Luigi Mangione Story · Dec 3, 2025 · 23m

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Luigi Mangione Could Have a Chance... Pre-Trial Motions in Luigi Mangione Case

Crime Talk with Scott Reisch · Dec 1, 2025 · 44m

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The Luigi Mangione Evidence Battle; ’Tis the Season… to Get Duped?

Here's the Scoop · Dec 1, 2025 · 20m

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NO FIRST-DEGREE MURDER CHARGES AGAINST LUIGI MANGIONE?

Crime Stories with Nancy Grace · Nov 30, 2025 · 43m

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I Saw Luigi Mangione In Court & This Is EVERYTHING That Happened

Rotten Mango · Oct 5, 2025 · 1h 25m

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From Overcharged to Death Penalty: Luigi Mangione & Tyler Robinson Updates

United Healthcare Murder: The Luigi Mangione Story · Sep 17, 2025 · 1h 7m

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Behind the memes: Luigi Mangione and Brian Thompson

The Mangione Trial · May 7, 2025 · 25m

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Who is Luigi Mangione and what’s he accused of?

The Mangione Trial · Feb 18, 2025 · 27m

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Who Is Luigi Mangione?

HBO · Feb 1, 2025

Watch

The 5,000% Markup: How UnitedHealth Profits from Cancer Patients

Delay, Deny, Depose: Luigi Mangione and the Assassination of UnitedHealthcare CEO Brian Thompson · Jan 18, 2025 · 8m

In-app player

The Shooting of the UnitedHealthcare CEO

20/20 · Jan 10, 2025

Watch

3 Dec 2024 - Arraignment Hearing

Full Trial Audio: Luigi Mangione · Jan 2, 2025 · 10m

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Luigi: The Making and the Meaning

John H. Richardson · Jan 1, 2025

Read

Luigi Mangione: Unraveling the Alleged United Healthcare CEO Assassin

Killer Psyche · Dec 24, 2024 · 54m

In-app player

Federal Criminal Complaint Against Luigi Mangione (SDNY, Dec 2024)

US District Court, SDNY · Dec 18, 2024

Open

3/ DisCypher: Inside the Mind of Tech Prodigy Luigi Mangione

Delay, Deny, Depose: Luigi Mangione and the Assassination of UnitedHealthcare CEO Brian Thompson · Dec 13, 2024 · 5m

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Arrest in UnitedHealthcare CEO murder. Drama at a Georgia sentencing. And Josh Mankiewicz on "Deadly Mirage."

Dateline NBC · Dec 12, 2024 · 28m

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Luigi Mangione- The Man Behind the Murder of UnitedHealthcare CEO

Luigi Mangione · Dec 11, 2024 · 5m

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Delay, Deny, Defend: Why Insurance Companies Don't Pay Claims and What You Can Do About It

Jay Feinman · Sep 7, 2010

Read

Untitled — The Luigi Mangione Case (forthcoming)

James Patterson and Vicky Ward

Read

UnitedHealthcare CEO shooting suspect's timeline before, during, after the brazen murder

ABC News

Open

Hand-drawn map, bus ticket, to-do list found on Luigi Mangione during arrest

Gothamist

Open

LUIGI — Full Podcast Series (Law&Crime / Wondery+)

LUIGI — Law&Crime / Wondery

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LUIGI Podcast — Apple Podcasts

LUIGI — Law&Crime / Wondery

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